参考文献:1. Chen, AY, Jemal, A, Ward, EM (2009) Increasing incidence of differentiated thyroid cancer in the United States, 1988鈥?005. Cancer 115: pp. 3801 CrossRef 2. Liu, X, He, M, Hou, Y, Liang, B, Zhao, L, Ma, S (2013) Expression profiles of microRNAs and their target genes in papillary thyroid carcinoma. Oncol. Rep. 29: pp. 1415 3. Taieb, D, Giusiano, S, Sebag, F, Marcy, M, Micco, C, Palazzo, FF (2010) Tumor protein p53-induced nuclear protein (TP53INP1) expression in medullary thyroid carcinoma: a molecular guide to the optimal extent of surgery?. World J. Surg. 34: pp. 830 CrossRef 4. Baumgartner, BG, Orpinell, M, Duran, J, Ribas, V, Burghardt, HE, Bach, D (2007) Identification of a novel modulator of thyroid hormone receptor-mediated action. PLoS One 2: pp. e1183 CrossRef 5. Haj-Ahmad, TA, Abdalla, MA, Haj-Ahmad, Y (2014) Potential urinary protein biomarker candidates for the accurate detection of prostate cancer among benign prostatic hyperplasia patients. J. Cancer 5: pp. 103 CrossRef 6. Wu, ZQ, Brabletz, T, Fearon, E, Willis, AL, Hu, CY, Li, XY (2012) Canonical Wnt suppressor, Axin2, promotes colon carcinoma oncogenic activity. Proc. Natl. Acad. Sci. U.S.A. 109: pp. 11312 CrossRef 7. Shirakihara, T, Kawasaki, T, Fukagawa, A, Semba, K, Sakai, R, Miyazono, K (2013) Identification of integrin alpha3 as a molecular marker of cells undergoing epithelial鈥搈esenchymal transition and of cancer cells with aggressive phenotypes. Cancer Sci. 104: pp. 1189 CrossRef 8. Gordon, GJ, Jensen, RV, Hsiao, LL, Gullans, SR, Blumenstock, JE, Ramaswamy, S (2002) Translation of microarray data into clinically relevant cancer diagnostic tests using gene expression ratios in lung cancer and mesothelioma. Cancer Res. 62: pp. 4963 9. Zou, KH, O鈥橫alley, AJ, Mauri, L (2007) Receiver-operating characteristic analysis for evaluating diagnostic tests and predictive models. Circulation 115: pp. 654 CrossRef 10. Lasko, TA, Bhagwat, JG, Zou, KH, Ohno-Machado, L (2005) The use of receiver operating characteristic curves in biomedical informatics. J. Biomed. Inform. 38: pp. 404 CrossRef 11. Wang, C, Crapo, LM (1997) The epidemiology of thyroid disease and implications for screening. Endocrinol. Metab. Clin. N. Am. 26: pp. 189 CrossRef 12. Gharib, H (2004) Changing trends in thyroid practice: understanding nodular thyroid disease. Endocr. Pract. 10: pp. 31 CrossRef 13. Prasad, NB, Somervell, H, Tufano, RP, Dackiw, AP, Marohn, MR, Califano, JA (2008) Identification of genes differentially expressed in benign versus malignant thyroid tumors. Clin. cancer Res. 14: pp. 3327 CrossRef 14. Cooper, DS, Doherty, GM, Haugen, BR, Kloos, RT, Lee, SL, Mandel, SJ (2009) Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer. Thyroid 19: pp. 1167 CrossRef 15. Guerra, A, Marotta, V, Deandrea, M, Motta, M, Limone, PP, Caleo, A (2013) BRAF (V600E) associates with cytoplasmatic localization of p27kip1 and higher cytokeratin 19 expression in papillary thyroid carcinoma. Endocrine 44: pp. 165 CrossRef 16. Di Benedetto G., Thyroid fine-needle aspiration: the relevance of BRAF mutation testing. Endocrine. 2014. doi:10.1007/s12020-014-0222-1 17. Seo J.Y, Kim E.K, Kwak J.Y, Additional BRAF mutation analysis may have additional diagnostic value in thyroid nodules with 鈥渟uspicious for malignant鈥?cytology alone even when the nodules do not show suspicious US features. Endocrine. 2014. doi:10.1007/s12020-013-0150-5 18. Guerra, A, Stasi, V, Zeppa, P, Faggiano, A, Marotta, V, Vitale, M (2014) BRAF (V600E) assessment by pyrosequencing in fine needle aspirates of thyroid nodules with concurrent Hashimoto鈥檚 thyroiditis is a reliable assay. Endocrine 45: pp. 249 CrossRef 19. Puxeddu, E, Filetti, S (2014) BRAF mutation assessment in papillary thyroid cancer: are we ready to use it in clinical practice?. Endocrine 45: pp. 341 CrossRef