Mangosteen xanthones suppress hepatitis C virus genome replication

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• 作者：Moonju Choi ; Young-Mi Kim ; Sungjin Lee ; Young-Won Chin ; Choongho Lee
• 关键词：Hepatitis C virus ; Mangosteen xanthones ; Replication inhibitor ; Anti ; oxidant ; Alpha ; mangostin ; Gamma ; mangostin
• 刊名：Virus Genes
• 出版年：2014
• 出版时间：October 2014
• 年：2014
• 卷：49
• 期：2
• 页码：208-222
• 全文大小：2,653 KB
• 参考文献：1. M.J. Alter, D. Kruszon-Moran, O.V. Nainan, G.M. McQuillan, F. Gao, L.A. Moyer, R.A. Kaslow, H.S. Margolis, New Engl. J. Med. 341, 556-62 (1999) CrossRef
  2. A.M. Di Bisceglie, Hepatology 31, 1014-018 (2000) CrossRef
  3. C.W. Shepard, L. Finelli, M.J. Alter, Lancet Infect. Dis 5, 558-67 (2005) CrossRef
  4. S. Mukherjee, M.F. Sorrell, Gastroenterology 134, 1777-788 (2008) CrossRef
  5. S.W. Ryter, H.P. Kim, A. Hoetzel, J.W. Park, K. Nakahira, X. Wang, A.M. Choi, Antioxid. Redox Signal 9, 49-9 (2007) CrossRef
  6. A. Grakoui, C. Wychowski, C. Lin, S.M. Feinstone, C.M. Rice, J. Virol. 67, 1385-395 (1993)
  7. G. Gloire, S. Legrand-Poels, J. Piette, Biochem. Pharmacol. 72, 1493-505 (2006) CrossRef
  8. H.M. Lander, FASEB J. 11, 118-24 (1997)
  9. A.V. Ivanov, B. Bartosch, O.A. Smirnova, M.G. Isaguliants, S.N. Kochetkov, Viruses 5, 439-69 (2013) CrossRef
  10. A.V. Ivanov, O.A. Smirnova, O.N. Ivanova, O.V. Masalova, S.N. Kochetkov, M.G. Isaguliants, PLoS ONE 6, e24957 (2011) CrossRef
  11. H.A. Jung, B.N. Su, W.J. Keller, R.G. Mehta, A.D. Kinghorn, J. Agric. Food Chem. 54, 2077-082 (2006) CrossRef
  12. X. Forns, R.H. Purcell, J. Bukh, Trends Microbiol. 7, 402-10 (1999) CrossRef
  13. K.J. Blight, A.A. Kolykhalov, C.M. Rice, Science 290, 1972-974 (2000) CrossRef
  14. P.D. Bryson, N.J. Cho, S. Einav, C. Lee, V. Tai, J. Bechtel, M. Sivaraja, C. Roberts, U. Schmitz, J.S. Glenn, Antiviral Res. 87, 1- (2010) CrossRef
  15. S.X. Chen, M. Wan, B.N. Loh, Planta Med. 62, 381-82 (1996) CrossRef
  16. Y.W. Chin, H.A. Jung, H. Chai, W.J. Keller, A.D. Kinghorn, Phytochemistry 69, 754-58 (2008) CrossRef
  17. Y.W. Chin, A.D. Kinghorn, Mini Rev. Org. Chem. 5, 355-64 (2008) CrossRef
  18. M.T. Chomnawang, S. Surassmo, V.S. Nukoolkarn, W. Gritsanapan, Fitoterapia 78, 401-08 (2007) CrossRef
  19. S.M. Al-Massarani, A.A. El Gamal, N.M. Al-Musayeib, R.A. Mothana, O.A. Basudan, A.J. Al-Rehaily, M. Farag, M.H. Assaf, K.H. El Tahir, L. Maes, Molecules 18, 10599-0608 (2013) CrossRef
  20. N. Fujita, R. Sugimoto, N. Ma, H. Tanaka, M. Iwasa, Y. Kobayashi, S. Kawanishi, S. Watanabe, M. Kaito, Y. Takei, J. Viral Hepat. 15, 498-07 (2008) CrossRef
  21. D.M. Tscherne, C.T. Jones, M.J. Evans, B.D. Lindenbach, J.A. McKeating, C.M. Rice, J. Virol. 80, 1734-741 (2006) CrossRef
  22. B.D. Lindenbach, M.J. Evans, A.J. Syder, B. Wolk, T.L. Tellinghuisen, C.C. Liu, T. Maruyama, R.O. Hynes, D.R. Burton, J.A. McKeating, C.M. Rice, Science 309, 623-26 (2005) CrossRef
  23. K.J. Blight, J.A. McKeating, C.M. Rice, J. Virol. 76, 13001-3014 (2002) CrossRef
  24. C. Lee, Biomol. Ther. 21, 97-06 (2013) CrossRef
  25. J. Zhang, G. Randall, A. Higginbottom, P. Monk, C.M. Rice, J.A. McKeating, J. Virol. 78, 1448-455 (2004) CrossRef
  26. M. Elazar, K.H. Cheong, P. Liu, H.B. Greenberg, C.M. Rice, J.S. Glenn, J. Virol. 77, 6055-061 (2003) CrossRef
  27. S.J. Kim, J.H. Kim, Y.G. Kim, H.S. Lim, J.W. Oh, J. Biol. Chem. 279, 50031-0041 (2004) CrossRef
  28. S.J. Kim, J.H. Kim, J.M. Sun, M.G. Kim, J.W. Oh, J. Viral Hepat. 16, 697-04 (2009) CrossRef
  29. D.G. Ahn, S.B. Shim, J.E. Moon, J.H. Kim, S.J. Kim, J.W. Oh, J. Viral Hepat. 18, e298–e306 (2011) CrossRef
  30. S. Baek, S.M. Kim, S.A. Lee, B.Y. Rhim, S.K. Eo, K. Kim, Biomol. Therap. 21, 42-8 (2013) CrossRef
  31. S. Yodhnu, A. Sirikatitham, C. Wattanapiromsakul, J. Chromatogr. Sci. 47, 185-89 (2009) CrossRef
  32. C. Lee, H. Ma, J.Q. Hang, V. Leveque, E.H. Sklan, M. Elazar, K. Klumpp, J.S. Glenn, Virology 414, 10-8 (2011) CrossRef
  33. G. Jin, S. Lee, M. Choi, S. Son, G. Kim, J. Oh, C. Lee, K. Lee, Eur. J. Med. Chem. 75, 413-25 (2014)
  34. J.A. Lemm, D. O’Boyle 2nd, M. Liu, P.T. Nower, R. Colonno, M.S. Deshpande, L.B. Snyder, S.W. Martin, D.R. St Laurent, M.H. Serrano-Wu, J.L. Romine, N.A. Meanwell, M. Gao, J. Virol. 84, 482-91 (2010) CrossRef
  35. C. Lee, Arch. Pharmacol. Res. 34, 1403-407 (2011) CrossRef
  36. M. Gao, R.E. Nettles, M. Belema, L.B. Snyder, V.N. Nguyen, R.A. Fridell, M.H. Serrano-Wu, D.R. Langley, J.H. Sun, D.R. O’Boyle 2nd, J.A. Lemm, C. Wang, J.O. Knipe, C. Chien, R.J. Colonno, D.M. Grasela, N.A. Meanwell, L.G. Hamann, Nature 465, 96-00 (2010) CrossRef
  37. Y.H. Choi, S.Y. Han, K. You-Jin, Y.M. Kim, Y.W. Chin, Food Chem. Toxicol. 66, 140-46 (2013) CrossRef
  38. J. Choi, K.J. Lee, Y. Zheng, A.K. Yamaga, M.M. Lai, J.H. Ou, Hepatology 39, 81-9 (2004) CrossRef
  39. S. Obeid, J. Alen, V.H. Nguyen, V.C. Pham, P. Meuleman, C. Pannecouque, T.N. Le, J. Neyts, W. Dehaen, J. Paeshuyse, PLoS ONE 8, e81783 (2013) CrossRef
  40. F. Farinati, R. Cardin, N. De Maria, L.G. Della, C. Marafin, E. Lecis, P. Burra, A. Floreani, A. Cecchetto, R. Naccarato, J. Hepatol. 22, 449-56 (1995) CrossRef
  41. M.P. Look, A. Gerard, G.S. Rao, T. Sudhop, H.P. Fischer, T. Sauerbruch, U. Spengler, Antiviral Res. 43, 113-22 (1999) CrossRef
  42. A.M. Rivas-Estilla, O.L. Bryan-Marrugo, K. Trujillo-Murillo, D. Perez-Ibave, C. Charles-Nino, C. Pedroza-Roldan, C. Rios-Ibarra, E. Ramirez-Valles, R. Ortiz-Lopez, M.C. Islas-Carbajal, N. Nieto, A.R. Rincon-Sanchez, Am. J. Physiol. 302, G1264–G1273 (2012)
  43. K. Shirabe, M. Shimada, K. Kajiyama, T. Gion, Y. Ikeda, H. Hasegawa, K. Taguchi, K. Takenaka, K. Sugimachi, Cancer 83, 2312-316 (1998) CrossRef
  44. K. Moriya, H. Fujie, Y. Shintani, H. Yotsuyanagi, T. Tsutsumi, K. Ishibashi, Y. Matsuura, S. Kimura, T. Miyamura, K. Koike, Nat. Med. 4, 1065-067 (1998) CrossRef
  45. J. Kato, M. Kobune, T. Nakamura, G. Kuroiwa, K. Takada, R. Takimoto, Y. Sato, K. Fujikawa, M. Takahashi, T. Takayama, T. Ikeda, Y. Niitsu, Cancer Res. 61, 8697-702 (2001)
  
• 作者单位：Moonju Choi (1)
  Young-Mi Kim (1)
  Sungjin Lee (1)
  Young-Won Chin (1)
  Choongho Lee (1)
  
  1. College of Pharmacy, Dongguk University-Seoul, Goyang, 410-050, South Korea
  
• ISSN：1572-994X

文摘

Hepatitis C virus (HCV) is a hepatotropic single-stranded RNA virus. HCV infection is causally linked with development of liver cirrhosis and hepatocellular carcinoma. Enhanced production of reactive oxygen species by HCV has been implicated to play an important role in HCV-induced pathogenesis. Mangosteen has been widely used as a traditional medicine as well as a dietary supplement ,thanks to its powerful anti-oxidant effect. In the present study, we demonstrated that the ethanol extract from mangosteen fruit peels (MG-EtOH) is able to block HCV genome replication using HCV genotype 1b Bart79I subgenomic (EC50 5.1?μg/mL) and genotype 2a J6/JFH-1 infectious replicon systems (EC50 3.8?μg/mL). We found that inhibition of HCV replication by MG-EtOH led to subsequent down-regulation of expression of HCV proteins. Interestingly, MG-EtOH exhibited a modest inhibitory effect on in vitro RNA polymerase activity of NS5B. Among a number of xanthones compounds identified within this MG-EtOH, we discovered α-MG (EC50 6.3?μM) and γ-MG (EC50 2.7?μM) as two major single molecules responsible for suppression of HCV replication. This finding will provide a valuable molecular basis to further develop mangosteen as an important dietary supplement to combat HCV-induced liver diseases.