Perfluorinated compounds are related to breast cancer risk in greenlandic inuit: A case control study
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- 作者：Eva C Bonefeld-Jorgensen (1)
Manhai Long (1)
Rossana Bossi (2)
Pierre Ayotte (3)
Gert Asmund (2)
Tanja Krüger (1)
Mandana Ghisari (1)
Gert Mulvad (4)
Peder Kern (4)
Peter Nzulumiki (4)
Eric Dewailly (3) - 关键词：PFCs ; POPs ; combined serum xenohormone and dioxin ; like activities ; n ; 3 fatty acids
- 刊名：Environmental Health
- 出版年：2011
- 出版时间：December 2011
- 年：2011
- 卷：10
- 期：1
- 全文大小：525KB
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Manhai Long (1)
Rossana Bossi (2)
Pierre Ayotte (3)
Gert Asmund (2)
Tanja Krüger (1)
Mandana Ghisari (1)
Gert Mulvad (4)
Peder Kern (4)
Peter Nzulumiki (4)
Eric Dewailly (3)
1. Centre for Arctic Environmental Medicine, Department of Public Health, Aarhus University, Aarhus, Denmark
2. National Environmental Research Institute, Aarhus University, Aarhus, Denmark
3. Institut National de Santé Publique du Québec, Québec, QC, Canada
4. Dronning Ingrids Hospital, Nuuk, Greenland
文摘
Background Breast cancer (BC) is the most common cancer for women in the western world. From very few cases an extraordinary increase in BC was observed in the Inuit population of Greenland and Canada although still lower than in western populations. Previous data suggest that exposure to persistent organic pollutants (POPs) might contribute to the risk of BC. Rat studies showed that perfluorinated compounds (PFCs) cause significantly increase in mammary fibroadenomas. This study aimed at evaluating the association between serum levels of POPs/PFCs in Greenlandic Inuit BC cases and their controls, and whether the combined POP related effect on nuclear hormone receptors affect BC risk. Methods Thirty-one BC cases and 115 controls were sampled during 2000-2003 from various Greenlandic districts. The serum levels of POPs, PFCs, some metals and the combined serum POP related effect on estrogen- (ER), androgen- (AR) and Ah-receptor (AhR) transactivity were determined. Independent student t-test was used to compare the differences and the odds ratios were estimated by unconditional logistic regression models. Results We observed for the very first time a significant association between serum PFC levels and the risk of BC. The BC cases also showed a significantly higher concentration of polychlorinated biphenyls at the highest quartile. Also for the combined serum POP induced agonistic AR transactivity significant association to BC risk was found, and cases elicited a higher frequency of samples with significant POP related hormone-like agonistic ER transactivity. The AhR toxic equivalent was lowest in cases. Conclusions The level of serum POPs, particularly PFCs, might be risk factors in the development of BC in Inuit. Hormone disruption by the combined serum POP related xenoestrogenic and xenoandrogenic activities may contribute to the risk of developing breast cancer in Inuit. Further investigations are needed to document these study conclusions.