Synthesis of pyrido[3,4-d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine
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- 作者：A. Yu. Kuznetsov ; N. L. Nam and S. V. Chapyshev
- 关键词：Ethyl 1 ; benzyl ; 3 ; oxopiperidine ; 4 ; carboxylate ; morpholine ; 4 ; carboxamidine ; pyrido[3 ; 4 ; d] ; pyrimidines ; condensation
- 刊名：Chemistry of Heterocyclic Compounds
- 出版年：2007
- 出版时间：May, 2007
- 年：2007
- 卷：43
- 期：5
- 页码：640-645
- 全文大小：203 KB
文摘
A method has been developed for the synthesis of 4-amino-substituted 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidines by condensation of ethyl 1-benzyl-3-oxopiperidine-4-carboxylate with morpholine-4-carboxamidine and subsequent reaction of the 7-benzyl-2-morpholin-4-yl-5,6,7,8-tetrahydro-3H-pyrido[3,4-d]pyrimidin-4-one with trifluoromethanesulfonic anhydride and secondary amines.