PdI2-Catalyzed Regioselective Cyclocarbonylation of 2-Allyl Phenols to Dihydrocoumarins
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- 作者：Manuel Am茅zquita-Valencia ; Howard Alper
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：November 21, 2014
- 年：2014
- 卷：16
- 期：22
- 页码：5827-5829
- 全文大小：244K
- ISSN：1523-7052
文摘
A simple, efficient, and regioselective synthesis of 3-methyl-3,4-dihydrocoumarins is reported. The reaction of 2-allyl phenols with synthesis gas was catalyzed by PdI2, and 1,3,5,7-tetramethyl-6-phenyl-2,4,8-trioxa-6-phosphaadamantane (L1) and 1,3,5,7-tetramethyl-6-tetradecyl-2,4,8-trioxa-6-phosphaadamantane (L2) were effective as ligands, affording good product selectivity in all cases.