Synthetic Advances Inspired by the Bioactive Dinitrosyl Iron Unit

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• 作者：Randara Pulukkody ; Marcetta Y. Darensbourg
• 刊名：Accounts of Chemical Research
• 出版年：2015
• 出版时间：July 21, 2015
• 年：2015
• 卷：48
• 期：7
• 页码：2049-2058
• 全文大小：593K
• ISSN：1520-4898

文摘

Resulting from biochemical iron鈥揘O interactions, dinitrosyl iron complexes (DNICs) are small organometallic-like molecules, considered to serve as vehicles for NO transport and storage in vivo. Formed by the interaction of NO with cellular iron sulfur clusters or with the cellular labile iron pool, DNICs have been documented to be the largest NO-derived adduct in cells, even surpassing the well-known nitrosothiols (RSNOs). Continuing efforts in biological chemistry are aimed at understanding the movement of DNICs in and out of cells, and their important role in NO-induced iron efflux leading to apoptosis in cells.