Cross-Coupling Hydrogen Evolution by Visible Light Photocatalysis Toward C(sp2)–P Formation: Metal-Free C–H Functionalization of Thiazole Derivatives with Diarylphosphine Oxides

详细信息    查看全文

• 作者：Kai Luo ; Yao-Zhong Chen ; Wen-Chao Yang ; Jie Zhu ; Lei Wu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：18
• 期：3
• 页码：452-455
• 全文大小：393K
• ISSN：1523-7052

文摘

Visible light along with 5 mol % eosin B catalyzed the first direct C–H phosphorylation of thiazole derivatives with diarylphosphine oxides by a photoredox process in the absence of an external oxidant. The scope of thiazoles and phosphine oxides was further investigated, as was functional group tolerance. The general and operational simplicity provides a novel metal and oxidant-free alternative for the formation of heteroaryl-P bonds, and only molecular hydrogen is generated as a byproduct.