Ligand-Free Pd-Catalyzed Domino Synthesis of Carbazoles via Dehydrogenative Aromatization/C(sp2)–C(sp2) Coupling Sequence

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• 作者：Lixian Wen ; Lin Tang ; Yu Yang ; Zhenggen Zha ; Zhiyong Wang
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1278-1281
• 全文大小：358K
• ISSN：1523-7052

文摘

A palladium-catalyzed domino reaction via a dehydrogenative aromatization and a dual C(sp²)–H functionalization process for one-pot synthesis of carbazoles under ligand-free conditions has been developed. On the basis of the catalytic system, carbazoles can be synthesized in moderate to good yields from facile arylamines and cyclic ketones, which presents straightforward and practical C(sp²)–C(sp²) bond formation.