Oxidative Aromatic C−O Bond Formation: Synthesis of 3-Functionalized Benzo[b]furans by FeCl3-Mediated Ring Closure of α-Aryl Ketones

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• 作者：Zhidan Liang ; Weizhe Hou ; Yunfei Du ; Yongliang Zhang ; Yan Pan ; Deng Mao ; Kang Zhao
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：November 5, 2009
• 年：2009
• 卷：11
• 期：21
• 页码：4978-4981
• 全文大小：251K
• 年卷期：v.11,no.21(November 5, 2009)
• ISSN：1523-7052

文摘

A variety of 3-functionalized benzo[b]furans were achieved by way of a FeCl₃-mediated intramolecular cyclization of electron-rich α-aryl ketones. The alkoxy substituent on the benzene ring in the substrates was essential for an efficient cyclization to occur. This novel method allows the construction of benzo[b]furan rings by joining the O-atom on the side chain to the benzene ring via direct oxidative aromatic C−O bond formation.