pH Controlled Release of Chromone from Chromone-Fe3O4 Nanoparticles

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• 作者：Baodui Wang ; Chenjie Xu ; Jin Xie ; Zhengyin Yang ; Shouheng Sun
• 刊名：Journal of the American Chemical Society
• 出版年：2008
• 出版时间：November 5, 2008
• 年：2008
• 卷：130
• 期：44
• 页码：14436-14437
• 全文大小：151K
• 年卷期：v.130,no.44(November 5, 2008)
• ISSN：1520-5126

文摘

We report a new strategy for coupling chromone to Fe₃O₄ nanoparticles. The chromone-Fe₃O₄ NP conjugate shows a dramatic increase in chromone solubility in cell culture medium from less than 2.5 to 633 μg/ml, leading to the enhanced chromone uptake by HeLa cells. Chromone can be released at low pH and as a result, the chromone-Fe₃O₄ conjugate is much more efficient in inhibiting the HeLa cell proliferation. Such chromone-Fe₃O₄ NPs are promising as a powerful multifunctional delivery system for both chromone-based diagnostic and therapeutic applications.