Adsorption of Doxorubicin on Poly(methyl methacrylate)鈥揅hitosan鈥揌eparin-Coated Activated Carbon Beads

详细信息    查看全文

• 作者：Jianjun Miao ; Fuming Zhang ; Majde Takieddin ; Shaker Mousa ; Robert J. Linhardt
• 刊名：Langmuir
• 出版年：2012
• 出版时间：March 6, 2012
• 年：2012
• 卷：28
• 期：9
• 页码：4396-4403
• 全文大小：454K
• 年卷期：v.28,no.9(March 6, 2012)
• ISSN：1520-5827

文摘

Extracorporeal filter cartridges, filled with an activated carbon bead (ACB) adsorbent, have been used for removal of overdosed cancer drugs from the blood. Coatings on adsorbent matrices, poly(methyl methacrylate) (PMMA)/activated carbon bead and PMMA/chitosan/heparin/ACB composites, were tested to improve their biocompatibility and blood compatibility. PMMA coating on ACBs was accomplished in a straightforward manner using a PMMA solution in ethyl acetate. A one-step hybrid coating of ACBs with PMMA鈥揳nticoagulant heparin required the use of acetone and water co-solvents. Multilayer coatings with three components, PMMA, chitosan, and heparin, involved three steps: PMMA was first coated on ACBs; chitosan was then coated on the PMMA-coated surface; and finally, heparin was covalently attached to the chitosan coating. Surface morphologies were studied by scanning electron microscopy. X-ray photoelectron spectroscopy confirmed the 鈭扴O₃^{鈥?/sup> group. Adsorption, of a chemotherapy drug (doxorubicin) from both water and phosphate-buffered saline, by the coated ACBs was examined. The adsorption isotherm curves were fitted using the Freundlich model. The current adsorption system might find potential applications in the removal of high-dose regional chemotherapy drugs while maintaining high efficiency, biocompatibility, and blood compatibility.}