Antiproliferative Triterpenes from Melaleuca ericifolia

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• 作者：Fatma M. Abdel Bar ; Ahmed M. Zaghloul ; Sunitha V. Bachawal ; Paul W. Sylvester ; Kadria F. Ahmad ; Khalid A. El Sayed
• 刊名：Journal of Natural Products
• 出版年：2008
• 出版时间：October 24, 2008
• 年：2008
• 卷：71
• 期：10
• 页码：1787-1790
• 全文大小：97K
• 年卷期：v.71,no.10(October 24, 2008)
• ISSN：1520-6025

文摘

Three new 28-norlupane triterpenes, 28-norlup-20(29)-en-3β-hydroxy-17β-hydroperoxide (1), 28-norlup-20(29)-en-3β-hydroxy-17α-hydroperoxide (2), and 20S-17β,29-epoxy-28-norlupan-3β-ol (3), were isolated from the leaves of Melaleuca ericifolia along with eight known pentacyclic triterpenes. The structures of the new compounds were elucidated by spectroscopic methods including 1D and 2D NMR spectroscopy and mass spectrometry. The isolated triterpenes were evaluated for antiproliferative activity against the malignant +SA mammary epithelial cell line.