tert-Butyl Hydroperoxide Mediated Cascade Synthesis of 3-Arylsulfonylquinolines

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• 作者：Liangliang Zhang ; Su Chen ; Yuzhen Gao ; Pengbo Zhang ; Yile Wu ; Guo Tang ; Yufen Zhao
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：March 18, 2016
• 年：2016
• 卷：18
• 期：6
• 页码：1286-1289
• 全文大小：349K
• ISSN：1523-7052

文摘

3-Arylsulfonylquinoline derivatives play important roles as pharmaceutical drugs. A new method for the synthesis of 3-arylsulfonylquinoline derivatives has been achieved through tert-butyl hydroperoxide mediated cycloaddition between N-propargyl aromatic amine derivatives and arylsulfonylhydrazides without the addition of any metals. This transformation offers a straightforward route to the formation of a C–S bond and quinoline ring in one step via a sulfonylation–cyclization–aromatization process.