Copper-Catalyzed Trifluoromethylselenolation of Aryl and Alkyl Halides: The Silver Effect in Transmetalation

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• 作者：Chaohuang Chen ; Chuanqi Hou ; Yuguang Wang ; T. S. Andy Hor ; Zhiqiang Weng
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：January 17, 2014
• 年：2014
• 卷：16
• 期：2
• 页码：524-527
• 全文大小：291K
• ISSN：1523-7052

文摘

A catalytic trifluoromethylselenolation of aryl and alkyl halides by a Cu(I) catalyst has been developed. A key intermediate, [(phen)Cu(SeCF₃)]₂ (5) was successfully isolated and characterized by X-ray diffraction. The important role of silver in the transmetalation process during the catalytic cycle was elucidated. A wide range of trifluoromethylselanes have been prepared from readily available starting materials from a method that tolerates various important functional groups.