Ruthenium(II)-Catalyzed Direct Addition of Indole/Pyrrole C2鈥揌 Bonds to Alkynes

详细信息    查看全文

• 作者：Libo Liang ; Shaomin Fu ; Dongen Lin ; Xiao-Qi Zhang ; Yuanfu Deng ; Huanfeng Jiang ; Wei Zeng
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：October 17, 2014
• 年：2014
• 卷：79
• 期：20
• 页码：9472-9480
• 全文大小：521K
• ISSN：1520-6904

文摘

A ruthenium-catalyzed C2-hydroindolation of alkynes has been achieved. This protocol provides a rapid and concise access to kinds of 2-alkenyl-substituted N-(2-pyridyl)indoles in which the pyridyl moiety can be easily removed to afford free (N鈥揌) indoles under mild conditions. Various arenes and alkynes, including electron-deficient and electron-rich internal alkynes and terminal alkynes, allow for this transformation.