C–H Activation Relay (CHAR): An Efficient Construction of Isatin Skeleton by Aerobic Oxidation of Glycine Esters

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• 作者：Xiaodong Jia ; Yingzu Zhu ; Yu Yuan ; Xuewen Zhang ; Shiwei Lü ; Liang Zhang ; Liangliang Luo
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：September 2, 2016
• 年：2016
• 卷：6
• 期：9
• 页码：6033-6036
• 全文大小：375K
• 年卷期：0
• ISSN：2155-5435

文摘

Directed by the strategy of C–H activation relay (CHAR), an efficient construction of isatin skeleton was developed through catalytic oxidation of glycine esters. The mechanistic study reveals that the oxidation of the relatively active C–H bonds initiated the followed activation of remote and inert C–H bonds, and an intramolecular 1,6-hydrogen shift was involved as a key step.