Structure and Bioassay of Triterpenoids and Steroids Isolated from Sinocalamus affinis

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• 作者：Liang Xiong ; Mei Zhu ; Chenggeng Zhu ; Sheng Lin ; Yongchun Yang ; Jiangong Shi
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：June 22, 2012
• 年：2012
• 卷：75
• 期：6
• 页码：1160-1166
• 全文大小：277K
• 年卷期：v.75,no.6(June 22, 2012)
• ISSN：1520-6025

文摘

Five triterpenoids with a new 25-norfern carbon skeleton (1鈥?b>5), a lupane triterpenoid (6), and four 20-hydroxyprogesterone acyl esters (7鈥?b>10), together with 23 known compounds, were isolated from the stem (with skin removed) of Sinocalamus affinis. The absolute configuration of compound 1 was confirmed by single-crystal X-ray crystallographic analysis using anomalous scattering of Cu K伪 radiation. Compounds 1鈥?b>5 exhibited inhibitory activity against protein tyrosine phosphatase 1B.