Rh(III)-Catalyzed C–C/C–N Coupling of Imidates with α-Diazo Imidamide: Synthesis of Isoquinoline-Fused Indoles

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• 作者：He Wang ; Lei Li ; Songjie Yu ; Yunyun Li ; Xingwei Li
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：18
• 期：12
• 页码：2914-2917
• 全文大小：377K
• 年卷期：0
• ISSN：1523-7052

文摘

Imidate esters and diazo compounds have been established as bifunctional substrates for the construction of biologically active fused heterocycles via rhodium-catalyzed C–H activation and C–C/C–N coupling. This reaction occurs under mild conditions with high efficiency, step economy, and low catalyst loading.