Hydration of Hydrophobic Iron鈥揅arbonyl Homopolymers via Water鈥揅arbonyl Interaction (WCI): Creation of Uniform Organometallic Aqueous Vesicles with Exceptionally High Encapsulation Capacity

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• 作者：Kai Cao ; Nimer Murshid ; Lu Li ; Anand Lopez ; Kam C. Tam ; Xiaosong Wang
• 刊名：Macromolecules
• 出版年：2015
• 出版时间：November 10, 2015
• 年：2015
• 卷：48
• 期：21
• 页码：7968-7977
• 全文大小：550K
• ISSN：1520-5835

文摘

Metal鈥揷arbonyl homopolymers (PFpPs) are hydrophobic but able to self-assemble in water into uniform and stable colloids. Hydrodynamic radius (R_h) of the colloids varies from 42 to 77 nm depending on preparation conditions. Light scattering, TEM, and AFM analyses of the colloids indicate that the colloids have a vesicular morphology with membrane thickness of ca. 3.0鈥?.0 nm. This thin membrane is, however, relatively rigid compared to conventional polymersomes. FT-IR and NMR analyses indicate that water鈥揷arbonyl interactions (WCI) is a motif responsible for the self-assembly and colloidal stability. By using nanoprecipitation encapsulation technique, PFpP vesicles can enclose hydrophilic molecules with extremely high encapsulation efficiency (EE) and loading capacity (LC). This work opens up a new research topic on hydration driven self-assembly and resolves a long-standing challenge of low EE and LC for the encapsulation of hydrophilic molecule via nanoprecipitation using amphiphilic molecules.