Polycyclic Hybrid Isoprenoids from a Reed Rhizosphere Soil Derived Streptomyces sp. CHQ-64

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• 作者：Qian Che ; Tianjiao Zhu ; Robert A. Keyzers ; Xiaofang Liu ; Jing Li ; Qianqun Gu ; Dehai Li
• 刊名：Journal of Natural Products
• 出版年：2013
• 出版时间：April 26, 2013
• 年：2013
• 卷：76
• 期：4
• 页码：759-763
• 全文大小：245K
• 年卷期：v.76,no.4(April 26, 2013)
• ISSN：1520-6025

文摘

Two new hybrid isoprenoids, named indotertine B (2) and drimentine H (3), along with the known analogue drimentine C (4), were isolated from the reed rhizosphere soil derived actinomycete Streptomyces sp. CHQ-64. The structures of these compounds, including absolute configurations, were elucidated by extensive NMR, MS, and CD analyses. Indotertine B (2) exists as a pair of rotamers about the N鈥揅(O) bond with a 2:1 ratio and displays activities against HCT-8 and A549 tumor cell lines with IC₅₀ values of 6.96 and 4.88 渭M, respectively.