文摘
Recently, two-dimensional transition metal dichalcogenides (TMDCs) have been widely studied in biomedicine. In this article, we developed a new photothermal nanocarrier based on polydopamine coated selenide molybdenum (MoSe<sub>2sub>@PDA) as an effective nanocarrier for loading anticancer drug doxorubicin (MoSe<sub>2sub>@PDA-Dox). Conjugation of PDA onto the surface of MoSe<sub>2sub> nanosheets can not only enhance the photothermal effect of MoSe<sub>2sub> nanosheets and decrease its cytotoxicity but also provide anchor points for loading Dox. The resulting MoSe<sub>2sub>@PDA nanocomposites exhibit good biocompatibility, good stability, and high photothermal conversion efficiency. The subsequent loading of anticancer drug doxorubicin (Dox) creates an efficient therapeutic agent with pH- and heat-responsive drug release. An in vivo experiment shows strong damage to tumor tissue, killing the tumor cell almost thoroughly. On that account, the MoSe<sub>2sub>@PDA-Dox nanocomposites may play a key role in cancer therapy in the future. Our work reveals the great promise of combing chemical and photothermal therapy to realize a synergistic effect for tumor treatment.