Enantioselective Bromocyclization of Olefins Catalyzed by Chiral Phosphoric Acid

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• 作者：Deshun Huang ; Haining Wang ; Fazhen Xue ; Huan Guan ; Lijun Li ; Xianyou Peng ; Yian Shi
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：December 16, 2011
• 年：2011
• 卷：13
• 期：24
• 页码：6350-6353
• 全文大小：837K
• 年卷期：v.13,no.24(December 16, 2011)
• ISSN：1523-7052

文摘

A chiral phosphoric acid catalyzed enantioselective bromocyclization of olefins is described. Various cis-, trans-, or trisubstituted 纬-hydroxy-alkenes and 纬-amino-alkenes can cyclize under the reaction conditions to give optically active 2-substituted tetrahydrofurans and tetrahydropyrroles in up to 91% ee.