Kinetic Control of Rh(III)-Catalyzed Annulation of C–H Bonds with Quinones: Chemoselective Synthesis of Hydrophenanthridinones and Phenanthridinones

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• 作者：Wei Yang ; Jingyi Wang ; Zhonglin Wei ; Qian Zhang ; Xianxiu Xu
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：February 19, 2016
• 年：2016
• 卷：81
• 期：4
• 页码：1675-1680
• 全文大小：482K
• ISSN：1520-6904

文摘

A temperature-dependent redox-neutral Rh(III)-catalyzed C–H bond annulation of N-methoxybenzamides with quinones was developed for the chemoselective synthesis of hydrophenanthridinones and phenanthridinones. This reaction involves an Rh(III)-catalyzed C–H bond functionalization and a subsequent cyclization through the directing group nucleophilic addition to the carbonyl group at room temperature.