Synthesis of 2,4,5-Trisubstituted Furans via a Triple C(sp3)–H Functionalization Reaction Using Rongalite as the C1 Unit

详细信息    查看全文

• 作者：Miao Wang ; Jia-Chen Xiang ; Yan Cheng ; Yan-Dong Wu ; An-Xin Wu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：18
• 期：3
• 页码：524-527
• 全文大小：386K
• ISSN：1523-7052

文摘

A highly efficient I₂/Cu(NO₃)₂·3H₂O-mediated triple C(sp³)–H functionalization reaction for the synthesis of 2,4,5-trisubstituted furans from aryl methyl ketones and rongalite by employing rongalite as a C1 unit has been developed. This method allows rapid access to (2-acyl-4-methylthio-5-aryl) furans. Preliminary mechanistic studies indicate that in situ generated dimethyl(phenacyl)-sulfonium iodine and HCHO were probably the key intermediates in this transformation.