Pseudolaridimers A and B, Hetero-Cycloartane鈥揕abdane Diels鈥揂lder Adducts from the Cone of Pseudolarix amabilis

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• 作者：Bo Li ; De-Yun Kong ; Yun-Heng Shen ; Hu Yuan ; Rong-Cai Yue ; Yi-Ren He ; Lu Lu ; Lei Shan ; Hui-Liang Li ; Ji Ye ; Xian-Wen Yang ; Juan Su ; Run-Hui Liu ; Wei-Dong Zhang
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：November 2, 2012
• 年：2012
• 卷：14
• 期：21
• 页码：5432-5435
• 全文大小：311K
• 年卷期：v.14,no.21(November 2, 2012)
• ISSN：1523-7052

文摘

Pseudolaridimers A (1) and B (2), two unprecedented heterodimers formed via a [4 + 2] Diels鈥揂lder cycloaddition between a cycloartane triterpenoid unit and a labdane diterpenoid unit, were isolated from the cones of Pseudolarix amabilis. Their structures were established by extensive analysis of HRESIMS and NMR spectra. The absolute configuration of 1 was determined by single crystal X-ray diffraction (CuK_伪) of its methyl esterified derivative. Pseudolaridimer A (1) showed strong cytotoxicity against HCT116, ZR-75-30, and HL-60 human tumor cell lines, with IC₅₀ values 9.62, 7.84, 8.29 渭g/mL, respectively. Pseudolaridimer B (2) only exhibited potent inhibition against the HL-60 cell line with an IC₅₀ value of 7.50 渭g/mL.