Correlation Study of Structural Parameters of Bioadhesive Polymers in Designing a Tunable Drug Delivery System
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- 作者：Baljit Singh ; Vikrant Sharma
- 刊名：Langmuir
- 出版年：2014
- 出版时间：July 22, 2014
- 年：2014
- 卷：30
- 期：28
- 页码：8580-8591
- 全文大小：508K
- ISSN：1520-5827
文摘
Keeping in view the importance of network structure in designing tunable drug delivery devices, in the present work, correlation between structural parameters and drug release profile has been determined for polysaccharide gum based polymers. These polymers have been characterized by SEMs, FTIR, 13C NMR, XRD, TGA/DTA/DTG, DSC, and swelling studies. The mechanical, biocompatible, and mucoadhesive properties of polymers have also been determined. The polymer network parameters such as polymer volume fraction in the swollen state, Flory鈥揌uggins interaction parameter, molecular weight of the polymer chain between two cross-links, cross-link density, and mesh size have been evaluated. Different kinetic models have been applied for the drug release profile of the antifungal drug fluconazole. The swelling and drug release occurred through a non-Fickian diffusion mechanism and a release profile best fitted in the Higuchi square root model. The polymers have been observed as non-thrombogenic, hemo-compatible, and mucoadhesive in nature and may be used in slow drug delivery applications to oral mucosa.