MDN-0104, an Antiplasmodial Betaine Lipid from Heterospora chenopodii
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- 作者：Jes煤s Mart铆n ; Gloria Crespo ; V铆ctor Gonz谩lez-Men茅ndez ; Guiomar P茅rez-Moreno ; Paula S谩nchez-Carrasco ; Ignacio P茅rez-Victoria ; Luis M. Ruiz-P茅rez ; Dolores Gonz谩lez-Pacanowska ; Francisca Vicente ; Olga Genilloud ; Gerald F. Bills ; Fernando Reyes
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：September 26, 2014
- 年：2014
- 卷：77
- 期：9
- 页码：2118-2123
- 全文大小：266K
- ISSN：1520-6025
文摘
Bioassay-guided fractionation of the crude fermentation extract of Heterospora chenopodii led to the isolation of a novel monoacylglyceryltrimethylhomoserine (1). The structure of this new betaine lipid was elucidated by detailed spectroscopic analysis using one- and two-dimensional NMR experiments and high-resolution mass spectrometry. Compound 1 displayed moderate in vitro antimalarial activity against Plasmodium falciparum, with an IC50 value of 7 渭M. This betaine lipid is the first monoacylglyceryltrimethylhomoserine ever reported in the Fungi, and its acyl moiety also represents a novel natural 3-keto fatty acid. The new compound was isolated during a drug discovery program aimed at the identification of new antimalarial leads from a natural product library of microbial extracts. Interestingly, the related fungus Heterospora dimorphospora was also found to produce compound 1, suggesting that species of this genus may be a promising source of monoacylglyceryltrimethylhomoserines.