Cytotoxic Cyclic Depsipeptides from the Australian Marine Sponge Neamphius huxleyi

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• 作者：Trong D. Tran ; Ngoc B. Pham ; Gregory Fechner ; Dusan Zencak ; Hoan T. Vu ; John N. A. Hooper ; Ronald J. Quinn
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：December 28, 2012
• 年：2012
• 卷：75
• 期：12
• 页码：2200-2208
• 全文大小：576K
• 年卷期：v.75,no.12(December 28, 2012)
• ISSN：1520-6025

文摘

Three new cyclic depsipeptides, neamphamides B (2), C (3), and D (4), were isolated from the Australian sponge Neamphius huxleyi. The planar structural characterization of these molecules was elucidated using 2D NMR experiments and ESI-FTICR-MSⁿ. Their configurations were determined by Marfey鈥檚 method and J-based NMR analysis. These new metabolites inhibited the growth of human cell lines (A549, HeLa, LNCaP, PC3, and NFF) with IC₅₀ values ranging from 88 to 370 nM. However, neamphamide D causes A549 cell proliferation at subcytotoxic doses and should be treated cautiously as a cytotoxic compound.