New Dendrimers: Synthesis and Characterization of POPAM−PAMAM Hybrid Dendrimers

详细信息    查看全文

• 作者：Istvn J. Majoros ; Christopher R. Williams ; Donald A. Tomalia ; James R. Baker
• 刊名：Macromolecules
• 出版年：2008
• 出版时间：November 25, 2008
• 年：2008
• 卷：41
• 期：22
• 页码：8372-8379
• 全文大小：407K
• 年卷期：v.41,no.22(November 25, 2008)
• ISSN：1520-5835

文摘

Recently developed multifunctional cancer therapeutic nanodevice production is based on poly(amidoamine) PAMAM generation 5 (G5) dendrimer as a carrier. Scale-up synthesis of this nanodevice is limited because of long reaction sequence (12 reaction steps) and long and not easy work-up of the products after each reaction step. Combination of poly(propylenimine) and poly(amidoamine) synthesis can improve the production of the drug carrier. In this paper we give a general overview of the synthesis and characterization of a series of novel hybrid dendrimers which we coined as novel POMAM hybrid dendrimers, constructed from poly(propylenimine) (PPI or POPAM) core and poly(amidoamine) PAMAM shells. The synthesis was accomplished by a divergent reiterating method involving repeating subsequent Michael addition and amidation reactions. Each generation of the newly synthesized dendrimer was characterized by using HPLC, GPC, NMR, and AFM.