Optically Detected Degradation of NaYF4:Yb,Tm-Based Upconversion Nanoparticles in Phosphate Buffered Saline Solution

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• 作者：Olivija Plohl ; Marco Kraft ; Janez Kovač ; Blaž Belec ; Maja Ponikvar-Svet ; Christian Würth ; Darja LisjakUte Resch-Genger
• 刊名：Langmuir
• 出版年：2017
• 出版时间：January 17, 2017
• 年：2017
• 卷：33
• 期：2
• 页码：553-560
• 全文大小：453K
• ISSN：1520-5827

文摘

In a proof-of-concept study, we assessed different analytical and spectroscopic parameters for stability screening of differently sized β-NaYF₄:20 mol % Yb³⁺, 2 mol % Tm³⁺ upconversion nanoparticles (UCNPs) exemplarily in the bioanalytically relevant buffer phosphate buffered saline (PBS; pH 7.4) at 37 and 50 °C. This included the potentiometric determination of the amount of released fluoride ions, surface analysis with X-ray photoelectron spectroscopy (XPS), and steady-state and time-resolved fluorescence measurements. Based on these results, the luminescence lifetime of the 800 nm upconversion emission was identified as an optimum parameter for stability screening of UCNPs and changes in particle surface chemistry.