Hydrogen-Bonded Helical Hydrazide Oligomers and Polymer That Mimic the Ion Transport of Gramicidin A

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• 作者：Pengyang Xin ; Pingping Zhu ; Pei Su ; Jun-Li Hou ; Zhan-Ting Li
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：September 24, 2014
• 年：2014
• 卷：136
• 期：38
• 页码：13078-13081
• 全文大小：293K
• ISSN：1520-5126

文摘

A new series of hydrogen-bonded helical aromatic hydrazide oligomers and polymer that bear phenylalanine tripeptide chains have been designed and synthesized. It was revealed that the helical structures could insert into lipid bilayers to form unimolecular channels. The longest oligomeric and polymeric helical channels exhibited an NH₄⁺/K⁺ selectivity that was higher than that of natural gramicidin A, whereas the transport of a short helical channel for Tl⁺ could achieve an efficiency as high as that of gramicidin A.