Pyridine Nucleosides Neopetrosides A and B from a Marine Neopetrosia sp. Sponge. Synthesis of Neopetroside A and Its 尾-Riboside Analogue
详细信息 查看全文
- 作者：Larisa K. Shubina ; Tatyana N. Makarieva ; Dmitry V. Yashunsky ; Nikolay E. Nifantiev ; Vladimir A. Denisenko ; Pavel S. Dmitrenok ; Sergey A. Dyshlovoy ; Sergey N. Fedorov ; Vladimir B. Krasokhin ; Seung Hun Jeong ; Jin Han ; Valentin A. Stonik
- 刊名：Journal of Natural Products
- 出版年：2015
- 出版时间：June 26, 2015
- 年：2015
- 卷：78
- 期：6
- 页码：1383-1389
- 全文大小：321K
- ISSN：1520-6025
文摘
Neopetrosides A (1) and B (2), new naturally occurring ribosides of nicotinic acid with extremely rare 伪-N-glycoside linkages and residues of p-hydroxybenzoic and pyrrole-2-carboxylic acids attached to C-5鈥? were isolated from a marine Neopetrosia sp. sponge. Structures 1 and 2 were determined by NMR and MS methods and confirmed by the synthesis of 1 and its 尾-riboside analogue (3). Neopetroside A (1) upregulates mitochondrial functions in cardiomyocytes.