Cisplatin Inhibits the Formation of a Reactive Intermediate during Copper-Catalyzed Oxidation of Amyloid 尾 Peptide

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• 作者：Gulshan R. Walke ; Srikanth Rapole ; Prasad P. Kulkarni
• 刊名：Inorganic Chemistry
• 出版年：2014
• 出版时间：October 6, 2014
• 年：2014
• 卷：53
• 期：19
• 页码：10003-10005
• 全文大小：222K
• ISSN：1520-510X

文摘

Cisplatin was studied for its effect on the copper-catalyzed oxidation of amyloid 尾 (A尾) peptide. The interaction of cisplatin with A尾1-16 in the presence of Cu^II was investigated using cyclic voltammetry and mass spectrometry. The positive shift in the E_1/2 value of A尾1-16-Cu^II suggests that the interaction of cisplatin alters the copper-binding properties of A尾1-16. The mass spectrometry data show complete inhibition of copper-catalyzed decarboxylation/deamination of the Asp1 residue of A尾1-16, while there is a significant decrease in copper-catalyzed oxidation of A尾1-16 in the presence of cisplatin. Overall, our results provide a novel mode by which cisplatin inhibits copper-catalyzed oxidation of A尾. These findings may lead to the design of better platinum complexes to treat oxidative stress in Alzheimer鈥檚 disease and other related neurological disorders.