Determination of Solubility and Induction Time of Ceftazidime

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• 作者：Dongya Zhang ; Yongli Wang ; Shuyuan Ma ; Songgu Wu ; Hongxun Hao
• 刊名：Journal of Chemical & Engineering Data
• 出版年：2013
• 出版时间：January 10, 2013
• 年：2013
• 卷：58
• 期：1
• 页码：176-182
• 全文大小：289K
• 年卷期：v.58,no.1(January 10, 2013)
• ISSN：1520-5134

文摘

The solubility of ceftazidime in pure water and in aqueous electrolyte solution with different pH values was measured by using the laser monitoring method in the temperature range of 278.15 K to 298.15 K. The modified Apelblat equation was adopted to investigate the dependency of the solubility on temperature. The dissolution enthalpy and entropy of ceftazidime were obtained by the van鈥檛 Hoff equation. To evaluate the effect of pH value on solubility, one model that was derived from the ionization equilibrium was applied to correlate the solubility data and pH values. Furthermore, the induction time for precipitation of ceftazidime was also determined at 283.15 K and 293.15 K by using the laser monitoring method. To investigate the crystallization mechanism of ceftazidime, five different models were used to evaluate the relationship between induction time and supersaturation by using the induction time data. It was found that the 2D nucleation mediated model gave the best results.