Cembrane-Type Diterpenoids from the Chinese Liverworts Chandonanthus hirtellus and C. birmensis
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- 作者：Rui-Juan Li ; Zhao-Min Lin ; Ya-Qi Kang ; Yan-Xia Guo ; Xin Lv ; Jin-Chuan Zhou ; Song Wang ; Hong-Xiang Lou
- 刊名：Journal of Natural Products
- 出版年：2014
- 出版时间：February 28, 2014
- 年：2014
- 卷：77
- 期：2
- 页码：339-345
- 全文大小：342K
- 年卷期：v.77,no.2(February 28, 2014)
- ISSN：1520-6025
文摘
Six new cembrane-type diterpenoids (1鈥?b>6) were isolated from two species of Chandonanthus: Chandonanones A, B, and D鈥揊 (1, 2, and 4鈥?b>6) were isolated from C. hirtellus, and chandonanones B, C, E, and F (2, 3, 5, and 6) from C. birmensis. Five known diterpenoids, (8E)-4伪-acetoxy-12伪,13伪-epoxycembra-1(15),8-diene (7), isochandonanthone (8), chandonanthone (9), anadensin (10), and 2,10,14-triacetoxy-7,8,18,19-diepoxydolabell-3(E)-ene (11), were also obtained. The structures of the new metabolites were established by analyses of their spectroscopic data (1D NMR, 2D NMR, HRESIMS, and IR). The absolute configurations of compounds 1 and 2 were unequivocally confirmed using single-crystal X-ray diffraction analysis with Cu K伪 radiation. Cytotoxicity tests of the isolated diterpenoids against seven cancer cell lines (DU145, PC3, A549, PC12, NCI-H292, NCI-H1299, and A172) revealed that some of the diterpenoids had weak activity.