Hierarchically Structured One-Dimensional TiO2 for Protein Immobilization, Direct Electrochemistry, and Mediator-Free Glucose Sensing

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• 作者：Peng Si ; Shujiang Ding ; Jun Yuan ; Xiong Wen (David) Lou ; Dong-Hwan Kim
• 刊名：ACS Nano
• 出版年：2011
• 出版时间：September 27, 2011
• 年：2011
• 卷：5
• 期：9
• 页码：7617-7626
• 全文大小：1171K
• 年卷期：0
• ISSN：1936-086X

文摘

A novel one-dimensional hierarchically structured TiO₂ (1DHS TiO₂) was synthesized by a solvothermal method using multiwalled carbon nanotubes (MWCNTs) as a template and evaluated for the immobilization of protein and biosensing applications. Characterization studies showed that the 1DHS TiO₂ possessed an anatase crystalline structure and a large surface area with narrow pore size distribution. Fast direct electron transfer was observed for glucose oxidase (GOx) immobilized on the 1DHS TiO₂, and excellent electrocatalytic performance for glucose detection can be obtained without a mediator. The glucose sensor based on the GOx/1DHS TiO₂-modified electrode had a high sensitivity of 9.90 μA mM^–1 cm^–2 and a low detection limit of 1.29 μM. The fabricated biosensor displayed good selectivity and long-term stability, indicating that the novel structured TiO₂ is a promising material for the immobilization of biomolecules and the fabrication of third-generation biosensors.