Synthesis and Characterization of Dual Modality (CT/MRI) Core−Shell Microparticles for Embolization Purposes

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• 作者：Aviv Hagit ; Bartling Soenke ; Budjan Johannes ; Margel Shlomo
• 刊名：Biomacromolecules
• 出版年：2010
• 出版时间：June 14, 2010
• 年：2010
• 卷：11
• 期：6
• 页码：1600-1607
• 全文大小：323K
• 年卷期：v.11,no.6(June 14, 2010)
• ISSN：1526-4602

文摘

Core P(MAOETIB-GMA) microparticles of 40−200 μm were prepared by suspension copolymerization of the iodinated monomer 2-methacryloyloxyethyl (2,3,5-triiodobenzoate), MAOETIB, with a low concentration of the monomer glycidyl methacrylate, GMA, which formed hydrophilic surfaces on the particles. Magnetic γ-Fe₂O₃/P(MAOETIB-GMA) core−shell microparticles were prepared by coating the aforementioned core particles through nucleation of iron oxide nanoparticles on the surfaces of the P(MAOETIB-GMA) particles. This was followed by stepwise growth of thin iron oxide layers. The radiopacity and magnetism of these particles were demonstrated in vitro by CT and MRI. In vivo embolization capabilities of these first multimodal visible embolization particles were demonstrated in a rat’s kidney tumor embolization model.