Cytotoxic neo-Clerodane Diterpenoid Alkaloids from Scutellaria barbata

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• 作者：Sheng-Jun Dai ; Wei-Bing Peng ; De-Wu Zhang ; Li Shen ; Wen-Yan Wang ; Yan Ren
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：October 23, 2009
• 年：2009
• 卷：72
• 期：10
• 页码：1793-1797
• 全文大小：180K
• 年卷期：v.72,no.10(October 23, 2009)
• ISSN：1520-6025

文摘

Six new neo-clerodane diterpenoid alkaloids, named scutehenanines A−D (1, 4, 5, 6), 6-O-acetylscutehenanine A (2), and 6-O-(2-carbonyl-3-methylbutanoyl)scutehenanine A (3), were isolated from the whole plant of Scutellaria barbata. Their structures were established on the basis of detailed physical data analyses. In vitro, the six new isolated compounds showed cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells) and gave IC₅₀ values in the range 2.8−6.4 μM.