Selective Alkylation of Amines with Alcohols by Cp*鈥揑ridium(III) Half-Sandwich Complexes

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• 作者：Alexander Wetzel ; Simone W枚ckel ; Mathias Schelwies ; Marion K. Brinks ; Frank Rominger ; Peter Hofmann ; Michael Limbach
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：January 18, 2013
• 年：2013
• 卷：15
• 期：2
• 页码：266-269
• 全文大小：280K
• 年卷期：v.15,no.2(January 18, 2013)
• ISSN：1523-7052

文摘

[Cp*Ir(Pro)Cl] (Pro = prolinato) was identified among a series of Cp*鈥搃ridium half-sandwich complexes as a highly reactive and selective catalyst for the alkylation of amines with alcohols. It is active under mild conditions in either toluene or water without the need for base or other additives, tolerates a wide range of alcohols and amines, and gives secondary amines in good to excellent isolated yields.