A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

详细信息    查看全文

• 作者：Won Il Choi ; Nazila Kamaly ; Lorena Riol-Blanco ; In-Hyun Lee ; Jun Wu ; Archana Swami ; Cristian Vilos ; Basit Yameen ; Mikyung Yu ; Jinjun Shi ; Ira Tabas ; Ulrich H. von Andrian ; Sangyong Jon ; Omid C. Farokhzad
• 刊名：Nano Letters
• 出版年：2014
• 出版时间：November 12, 2014
• 年：2014
• 卷：14
• 期：11
• 页码：6449-6455
• 全文大小：394K
• ISSN：1530-6992

文摘

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Keywords:

Nanoparticles; thermosponge; solvent-free; therapeutic proteins; biologics