Cytotoxic Prenylated Acetophenone Dimers from Acronychia pedunculata

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• 作者：Eirini Kouloura ; Maria Halabalaki ; Marie-Christine Lallemand ; Sangkil Nam ; Richard Jove ; Marc Litaudon ; Khalijah Awang ; Hamid A. Hadi ; Alexios-Leandros Skaltsounis
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：July 27, 2012
• 年：2012
• 卷：75
• 期：7
• 页码：1270-1276
• 全文大小：269K
• 年卷期：v.75,no.7(July 27, 2012)
• ISSN：1520-6025

文摘

Three new acetophenone dimers or Acronychia-type acetophenones, acropyrone (1), acropyranol A (2), and acropyranol B (3), were isolated from the trunk bark of Acronychia pedunculata and structurally characterized, together with four known acetophenone dimers, acrovestone (4), acrovestenol (5), acrofolione A (6), and acrofolione B (7), the acetophenone monomer acronyline (8), and four furoquinoline alkaloids. The chemical structures of the new isolated compounds were elucidated unambiguously by spectroscopic data analysis. The cytotoxic activities of the isolated acetophenone dimers were evaluated against the DU145 prostate and A2058 melanoma human cancer cell lines as well as the NHDF normal cell line. Acrovestone (4) and acrovestenol (5) exhibited substantial cytotoxicity, with IC₅₀ values of 0.38 and 2.8 渭M against A2058 melanoma cells as well as 0.93 and 2.7 渭M against DU145 prostate cancer cells, respectively.