Mohangic Acids A–E, p-Aminoacetophenonic Acids from a Marine-Mudflat-Derived Streptomyces sp.
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- 作者：Munhyung Bae ; Kyuho Moon ; Jihye Kim ; Hyen Joo Park ; Sang Kook Lee ; Jongheon Shin ; Dong-Chan Oh
- 刊名：Journal of Natural Products
- 出版年：2016
- 出版时间：February 26, 2016
- 年：2016
- 卷：79
- 期：2
- 页码：332-339
- 全文大小：370K
- ISSN：1520-6025
文摘
Mohangic acids A–E (1–5) were isolated from a marine Streptomyces sp. collected from a mudflat in Buan, Republic of Korea. Comprehensive spectroscopic analysis revealed that the mohangic acids are new members of the p-aminoacetophenonic acid class. The relative and absolute configurations of the mohangic acids were determined by J-based configuration analysis and by the application of bidentate chiral NMR solvents followed by 13C NMR analysis, chemical derivatization, and circular dichroism spectroscopy. Mohangic acid E (5), which is the first glycosylated compound in the p-aminoacetophenonic acid family, displayed significant quinone reductase induction activity.