Simulating the Embolization of Blood Vessels Using Magnetic Microparticles and Acupuncture Needle in a Magnetic Field
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- 作者：Ovidiu Rotariu ; Gheorghe Iacob ; Norval J. C. Strachan ; and Horia Chiriac
- 刊名：Biotechnology Progress
- 出版年：2004
- 出版时间：February 2004
- 年：2004
- 卷：20
- 期：1
- 页码：299 - 305
- 全文大小：124K
- 年卷期：v.20,no.1(February 2004)
- ISSN：1520-6033
文摘
Computer models were developed to simulate the capture and subsequent depositionof magnetic microparticles (MMPs) in a blood vessel adjacent to a ferromagnetic wire(e.g., acupuncture needle) magnetized by a uniform external magnetic field. Processparameter conditions were obtained to enable optimal capture of MMPs into thedeposit. It was found that the maximum capture distance of the MMPs was within0.5-2.0 mm when the particles were superparamagnetic and had large size (>1.0
m) and relative large flow rates (2.5-5.0 cm/s) as in a healthy artery. It was alsofound that the deposits were asymmetrical and that their size was between 1.0 and2.0 mm. For the case of lower flow rates as can be found in a tumor (<1.0 mm/s) andusing small magnetite particles (0.25-2.0 m) the maximum capture distance waslarger, ranging between approximately 0.5 and 6.4 mm, depending on the blood flowrate, the radius of wire, and particle clustering. The range of embolization (deposition)in this later case was between 0.5 and 5.9 mm. The potential of this technique togenerate MMPs deposits to embolize blood vessels inhibiting the blood supply andthus facilitating necrosis of tumors located deep within the patient (3-7 cm) isdiscussed.
m) and relative large flow rates (2.5-5.0 cm/s) as in a healthy artery. It was alsofound that the deposits were asymmetrical and that their size was between 1.0 and2.0 mm. For the case of lower flow rates as can be found in a tumor (<1.0 mm/s) andusing small magnetite particles (0.25-2.0 m) the maximum capture distance waslarger, ranging between approximately 0.5 and 6.4 mm, depending on the blood flowrate, the radius of wire, and particle clustering. The range of embolization (deposition)in this later case was between 0.5 and 5.9 mm. The potential of this technique togenerate MMPs deposits to embolize blood vessels inhibiting the blood supply andthus facilitating necrosis of tumors located deep within the patient (3-7 cm) isdiscussed.