Nanorods Formed from a New Class of Peptidomimetics

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• 作者：Youhong Niu ; Haifan Wu ; Rongfu Huang ; Qiao Qiao ; Frankie Costanza ; Xi-Sen Wang ; Yaogang Hu ; Mohamad Nassir Amin ; Anh-My Nguyen ; James Zhang ; Edward Haller ; Shengqian Ma ; Xiao Li ; Jianfeng Cai
• 刊名：Macromolecules
• 出版年：2012
• 出版时间：September 25, 2012
• 年：2012
• 卷：45
• 期：18
• 页码：7350-7355
• 全文大小：367K
• 年卷期：v.45,no.18(September 25, 2012)
• ISSN：1520-5835

文摘

Although peptide amphiphiles have been explored as nanomaterials for different applications, nanostructures formed by hierarchical molecular assembly of sequence-specific peptidomimetics are much less developed. Such protein-like nanomaterials could enhance the current application of peptide-based amphiphiles by enriching the diversity of nanostructures, increasing in vivo stability for biomedical applications, and facilitating the understanding of biomacromolecular self-assembly. Herein we present a biomimetic 纬-AApeptide amphiphile which forms nanorods. Our results demonstrate the capability of 纬-AApeptide amphiphiles as a potential scaffold for the preparation of biomimetic and bioinspired nanostructures. The programmability and biocompatibility of 纬-AApeptides could lead to novel nanomaterials for a wide variety of applications.