One-Pot Synthesis of Highly Substituted Aromatic Amine Derivatives via Pd-Catalyzed Aminobenzannulation Reaction

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• 作者：Fa-Rong Gou ; Peng-Fei Huo ; Hai-Peng Bi ; Zheng-Hui Guan ; Yong-Min Liang
• 刊名：Organic Letters
• 出版年：2009
• 出版时间：August 6, 2009
• 年：2009
• 卷：11
• 期：15
• 页码：3418-3421
• 全文大小：217K
• 年卷期：v.11,no.15(August 6, 2009)
• ISSN：1523-7052

文摘

A novel and convenient Pd(0)-catalyzed carboannulation with propargylic compounds for the synthesis of highly substituted aromatic amine derivatives in a one-pot operation was developed. In this process, a significant breakthrough in aminobenzannulation is observed. Moreover, the reaction appears to be very general and suitable for a variety of amines.