Influenza A (H1N1) Antiviral and Cytotoxic Agents from Ferula assa-foetida

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• 作者：Chia-Lin Lee ; Lien-Chai Chiang ; Li-Hung Cheng ; Chih-Chuang Liaw ; Mohamed H. Abd El-Razek ; Fang-Rong Chang ; Yang-Chang Wu
• 刊名：Journal of Natural Products
• 出版年：2009
• 出版时间：September 25, 2009
• 年：2009
• 卷：72
• 期：9
• 页码：1568-1572
• 全文大小：188K
• 年卷期：v.72,no.9(September 25, 2009)
• ISSN：1520-6025

文摘

Two new sesquiterpene coumarins, designated 5′-acetoxy-8′-hydroxyumbelliprenin (1) and 10′R-acetoxy-11′-hydroxyumbelliprenin (2), and a new diterpene, 15-hydroxy-6-en-dehydroabietic acid (3), along with 27 known compounds, were isolated from a CHCl₃-soluble extract of Ferula assa-foetida through bioassay-guided fractionation. The structures of the new metabolites 1−3 were identified by spectroscopic data interpretation and by the Mosher ester method. Compounds 4 and 6−13 showed greater potency against influenza A virus (H₁N₁) (IC₅₀ 0.26−0.86 μg/mL) than amantadine (IC₅₀ 0.92 μg/mL), and 11 exhibited the best potency (IC₅₀ 0.51, 2.6, and 3.4 μg/mL) of these compounds against the HepG2, Hep3B, and MCF-7 cancer cell lines, respectively.