Synthesis of α-Quaternary Formimides and Aldehydes through Umpolung Asymmetric Copper Catalysis with Isocyanides

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• 作者：Kentaro Hojoh ; Hirohisa Ohmiya ; Masaya Sawamura
• 刊名：Journal of the American Chemical Society
• 出版年：2017
• 出版时间：February 15, 2017
• 年：2017
• 卷：139
• 期：6
• 页码：2184-2187
• 全文大小：371K
• ISSN：1520-5126

文摘

A highly regio- and enantioselective copper-catalyzed three-component coupling of isocyanides, hydrosilanes, and γ,γ-disubstituted allylic phosphates/chlorides to afford chiral α-quaternary formimides was enabled by the combined use of our original chiral naphthol–carbene ligand as a functional Cu-supporting ligand and LiOtBu as a stoichiometric Lewis base for Si. The formimides were readily converted to α-quaternary aldehydes.