Schizanthines N, O, and P, Tropane Alkaloids from the Aerial Parts of Schizanthus tricolor

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• 作者：Munir Humam ; Thomas Kehrli ; Damien Jeannerat ; Orlando Mun虄oz ; Kurt Hostettmann ; Philippe Christen
• 刊名：Journal of Natural Products
• 出版年：2011
• 出版时间：January 28, 2011
• 年：2011
• 卷：74
• 期：1
• 页码：50-53
• 全文大小：132K
• 年卷期：v.74,no.1(January 28, 2011)
• ISSN：1520-6025

文摘

Three tropane alkaloids, named schizanthines N, O, and P (1鈭?b>3), have been isolated from the crude alkaloid extract of the endemic Chilean plant Schizanthus tricolor. On the basis of extensive NMR studies and MS fragmentation analysis, their structures were determined to be 3伪-(E)-4-hydroxysenecioyloxy-6尾-angeloyloxytropane (1), 3伪-(E)-4-hydroxysenecioyloxy-6尾-senecioyloxytropane (2), and 3伪-mesaconyloxy-6尾-senecioyloxytropane (3). Compounds 1 and 2 are the first isomeric alkaloids in the tropane series possessing a hydroxysenecioyl substituent as an esterifying moiety.