Synthesis of Optically Active Bifunctional Building Blocks through Enantioselective Copper-Catalyzed Allylic Alkylation Using Grignard Reagents

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• 作者：Anthoni W. van Zijl ; Fernando L&oacute ; pez ; Adriaan J. Minnaard ; Ben L. Feringa
• 刊名：Journal of Organic Chemistry
• 出版年：2007
• 出版时间：March 30, 2007
• 年：2007
• 卷：72
• 期：7
• 页码：2558 - 2563
• 全文大小：113K
• 年卷期：v.72,no.7(March 30, 2007)
• ISSN：1520-6904

文摘

LE>jo0625655n00002>journals/joceah/72/i07/figures/jo0625655n00002.gif" ALIGN="left" HSPACE=5>Enantioselective copper-catalyzed allylic alkylations were performed on allylic bromides with a protectedhydroxyl or amine functional group using several Grignard reagents and Taniaphos L1 as a ligand. Theterminal olefin moiety in the products was transformed into various functional groups without racemization,providing facile access to a variety of versatile bifunctional chiral building blocks.