Four substituted 4
H-benzo[1,2,4]thi
adiazines
2 were prepared by condensation of the appropriate anilinesand benzonitriles followed by oxidative cyclization. The preparation of three fluorinated derivatives
2b-2d proceeded smoothly, while the synthesis of
2a was problematic, presumably due to the relativelyhigh electron density of the benzene ring. The four-ring derivatives
2c and
2d exhibited liquid crystallineproperties (
2c: Cr 95 SmA 158 I and
2d: Cr 142 SmA 212 I). 4
H-Benzo[1,2,4]thi
adiazines
2 wereoxidized with AgO to generate the corresponding persistent r
adicals
1 (
g = 2.0057). The stability of ther
adicals followed the order
1b ~
1d >
1c 1a, and the two fluorinated r
adicals
1b and
1d were isolatedas crude solids. The lower stability of
1c is presumably due to the presence of the reactive benzylic CHposition, and
1a lacks the stabilizing effect of the three fluorine atoms. ESR spectra for
1 were simulatedusing DFT-derived hfcc as the starting point.